Harlequins make four changes to the side which lost to Wasps last weekend.
England international Joe Marler, Rob Buchanan and Kyle Sinckler form a new front-row partnership and Nick Evans returns at fly-half.
Captain Tom Wood returns for Northampton, one of five changes to the XV which beat Exeter Chiefs.
Full-back Ahsee Tuala, centre Luther Burrell and fly-half Stephen Myler are named in the back line, while Teimana Harrison is back at number eight.
Harlequins have won both of their home games so far this season, but Saints have been victorious in the last seven meetings between the two sides in all competitions.
Source: BBC Sport
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